Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation

被引：23

作者：

Sollogoub, M

Dominguez, B

Fox, KR

Brown, T ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Sch Biol Sci, Div Biochem & Mol Biol, Southampton SO17 7PX, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 23期

关键词：

D O I：

10.1039/b006268p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel thymidine analogue containing both 5-aminopropargyl and 2'-aminoethoxy modifications has been synthesised and incorporated into a triplex-forming oligonucleotide; the combination of the two amino groups on the same nucleoside greatly enhances triplex stability.

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收藏

页码：2315 / 2316

页数：2

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