Surfing the p53 network

被引：5738

作者：

Vogelstein, B ^{[1
]}

Lane, D

Levine, AJ

机构：

[1] Howard Hughes Med Inst, Baltimore, MD 21231 USA

[2] Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA

[3] Univ Dundee, Ninewells Hosp, Dept Surg & Mol Oncol, Dundee DD1 5EH, Scotland

[4] Rockefeller Univ, Lab Canc Biol Genet & Mol Biophys, New York, NY 10021 USA

来源：

NATURE | 2000年 / 408卷 / 6810期

关键词：

D O I：

10.1038/35042675

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.

引用

页码：307 / 310

页数：4

共 41 条

[1] Error and attack tolerance of complex networks [J].

Albert, R ;

Jeong, H ;

Barabási, AL .

NATURE, 2000, 406 (6794) :378-382

[2] Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study [J].

Bar-Or, RL ;

Maya, R ;

Segel, LA ;

Alon, U ;

Levine, AJ ;

Oren, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11250-11255

[3] Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome [J].

Bell, DW ;

Varley, JM ;

Szydlo, TE ;

Kang, DH ;

Wahrer, DCR ;

Shannon, KE ;

Lubratovich, M ;

Verselis, SJ ;

Isselbacher, KJ ;

Fraumeni, JF ;

Birch, JM ;

Li, FP ;

Garber, JE ;

Haber, DA .

SCIENCE, 1999, 286 (5449) :2528-2531

[4] RETRACTED: SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53 (Retracted Article) [J].

Buschmann, T ;

Fuchs, SY ;

Lee, CG ;

Pan, ZQ ;

Ronai, Z .

CELL, 2000, 101 (07) :753-762

[5] Cell cycle - Piecing together the p53 puzzle [J].

Carr, AM .

SCIENCE, 2000, 287 (5459) :1765-1766

[6] 14-3-3σ is required to prevent mitotic catastrophe after DNA damage [J].

Chan, TA ;

Hermeking, H ;

Lengauer, C ;

Kinzler, KW ;

Vogelstein, B .

NATURE, 1999, 401 (6753) :616-620

[7] Downregulation of 14-3-3σ prevents clonal evolution and leads to immortalization of primary human keratinocytes [J].

Dellambra, E ;

Golisano, O ;

Bondanza, S ;

Siviero, E ;

Lacal, P ;

Molinari, M ;

D'Atri, S ;

De Luca, M .

JOURNAL OF CELL BIOLOGY, 2000, 149 (05) :1117-1129

[8]

Dotto GP, 1999, CRIT REV ORAL BIOL M, V10, P442

[9] Regulation of p53 downstream genes [J].

El-Deiry, WS .

SEMINARS IN CANCER BIOLOGY, 1998, 8 (05) :345-357

[10] Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity [J].

Franklin, DS ;

Godfrey, VI ;

O'Brien, DA ;

Deng, CX ;

Xiong, Y .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (16) :6147-6158

← 1 2 3 4 5 →