Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury

被引：19

作者：

Boskabady, Mostafa ^{[1
,2
]}

Khazdair, Mohammad Reza ^{[3
]}

Bargi, Rahimeh ^{[2
]}

Saadat, Saeideh ^{[4
]}

Memarzia, Arghavan ^{[2
]}

Mohammadian Roshan, Nema ^{[5
]}

Hosseini, Mahmoud ^{[1
,2
,6
]}

Askari, Vahid Reza ^{[1
,7
]}

Boskabady, Mohammad Hossein ^{[1
,2
]}

机构：

[1] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Dept Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

[3] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran

[4] Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran

[5] Mashhad Univ Med Sci, Dept Pathol, Fac Med, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Div Neurocognit Sci, Psychiat & Behav Sci Res Ctr, Mashhad, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Sch Persian & Complementary Med, Dept Pharmaceut Sci Persian Med, Mashhad, Razavi Khorasan, Iran

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2021年 / 2021卷

关键词：

D O I：

10.1155/2021/6681729

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Anti-inflammatory, antioxidant, and immunomodulatory effects of thymoquinone (TQ) have been shown. The effects of TQ on lipopolysaccharide- (LPS-) induced inflammation and pathological changes in rats' lung were investigated in this study. Four groups of rats included (1) control (saline treated); (2) LPS (treated with 1 mg/kg/day i.p. for two weeks); and (3 and 4) 5 or 10 mg/kg TQ i.p. 30 min prior to LPS administration. Total and differential WBC counts in the blood and bronchoalveolar fluid (BALF), TGF-beta 1, INF-gamma, PGE2, and IL-4 levels in the BALF and pathological changes of the lung were evaluated. Total WBC count and eosinophil, neutrophil, and monocyte percentage were increased, but the lymphocyte percentage was reduced in the blood and BALF. The BALF levels of PGE2, TGF-beta 1, and INF-gamma were also increased, but IL-4 level was reduced due to LPS administration. LPS also induced pathological insults in the lung of rats (P<0.05 to P<0.001 for all changes in LPS-exposed animals). Treatment with TQ showed a significant improvement in all changes induced by LPS (P<0.05 to P<0.05). TQ showed a protective effect on LPS-induced lung inflammation and pathological changes in rats which suggested a therapeutic potential for TQ on lung injury.

引用

页数：10

共 43 条

[1]

<bold>Thymoquinone ameliorates pulmonary vascular damage induced by</bold>Escherichia coli-<bold>derived lipopolysaccharide via cytokine downregulation in rats</bold> [J].