In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands

被引:36
作者
Renkonen, R
Mattila, P
Majuri, ML
Rabina, J
Toppila, S
Renkonen, J
Hirvas, L
Niittymaki, J
Turunen, JP
Renkonen, O
Paavonen, T
机构
[1] UNIV HELSINKI, HAARTMAN INST, DEPT PATHOL, SF-00014 HELSINKI, FINLAND
[2] UNIV HELSINKI, INST BIOTECHNOL, SF-00014 HELSINKI, FINLAND
基金
芬兰科学院;
关键词
metastasis; leukocytes; sialyl Lewis x; sialyl Lewis a; endothelial; carcinoma; glycans; selectin;
D O I
10.1023/A:1018536509950
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extravasation from the blood of malignant tumour cells that form metastasis and leukocytes that go into tissues require contact between selectins and their sialyl Lewis x and sialyl Lewis a (sLe(x) and sLe(a) respectively) decorated ligands. Endothetial cells have been shown to express sLe(x) epitopes in lymph nodes and at sites of inflammation, and this is crucial for the selectin-dependent leukocyte traffic. Besides the ability to synthesize sLe(x) on sialylated N-acetyllactosamine vie the action of a(1,3)fucosyltransferase(s), endothelial cells can also degrade sLe(x) to Lewis x through the action of a(2,3)sialidase(s). In addition, several epithelial tumors possess the machinery to synthesize sLe(x), which facilitates their adhesion to endothelial E- and P-selectin.
引用
收藏
页码:593 / 600
页数:8
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