T-independent immune response: New aspects of B cell biology

被引：300

作者：

Fagarasan, S ^{[1
]}

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan

来源：

SCIENCE | 2000年 / 290卷 / 5489期

关键词：

D O I：

10.1126/science.290.5489.89

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various Lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.

引用

页码：89 / 92

页数：4

共 28 条

[1] [Anonymous], UNPUB
[2] Monoclonal immunoglobulin a derived from peritoneal B cells is encoded by both germ line and somatically mutated V-H genes and is reactive with commensal bacteria
Bos, NA
Bun, JCAM
Popma, SH
Cebra, ER
Deenen, GJ
vanderCammen, MJF
Kroese, FGM
Cebra, JJ
[J]. INFECTION AND IMMUNITY, 1996, 64 (02) : 616 - 623
[3] C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
Dempsey, PW
Allison, MED
Akkaraju, S
Goodnow, CC
Fearon, DT
[J]. SCIENCE, 1996, 271 (5247) : 348 - 350
[4] Alymphoplasia (aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
Fagarasan, S
Shinkura, R
Kamata, T
Nogaki, F
Ikuta, K
Tashiro, K
Honjo, T
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) : 1477 - 1486
[5] Fagarasan S, 2000, IMMUNOL REV, V176, P205
[6] FREEMAN GJ, IN PRESS J EXP MED
[7] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Gross, JA
Johnston, J
Mudri, S
Enselman, R
Dillon, SR
Madden, K
Xu, WF
Parrish-Novak, J
Foster, D
Lofton-Day, C
Moore, M
Littau, A
Grossman, A
Haugen, H
Foley, K
Blumberg, H
Harrison, K
Kindsvogel, W
Clegg, CH
[J]. NATURE, 2000, 404 (6781) : 995 - 999
[8] Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
Guinamard, R
Okigaki, M
Schlessinger, J
Ravetch, JV
[J]. NATURE IMMUNOLOGY, 2000, 1 (01) : 31 - 36
[9] THE LY-1-B CELL SUBPOPULATION IN NORMAL, IMMUNODEFECTIVE, AND AUTOIMMUNE MICE
HAYAKAWA, K
HARDY, RR
PARKS, DR
HERZENBERG, LA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 157 (01) : 202 - 218
[10] INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH
ISHIDA, Y
AGATA, Y
SHIBAHARA, K
HONJO, T
[J]. EMBO JOURNAL, 1992, 11 (11) : 3887 - 3895

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