Constitutive amplification of a zinc finger protein gene in cattle

被引：8

作者：

LeChalony, C ^{[1
]}

Apiou, F ^{[1
]}

Pibouin, L ^{[1
]}

Dutrillaux, B ^{[1
]}

Goubin, G ^{[1
]}

机构：

[1] INST CURIE,UMR 147 CNRS,F-75231 PARIS 05,FRANCE

来源：

DNA AND CELL BIOLOGY | 1996年 / 15卷 / 01期

关键词：

D O I：

10.1089/dna.1996.15.83

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human OZF gene encodes a protein consisting essentially of zinc finger moths of the Kruppel type. Evolutionary studies revealed amplification of the bovine OZF gene in cattle. Domestic cattle includes two major subspecies: taurine (Bos primigenius taurus) and zebu (B. p. indicus). Amplified sequences were found in both subspecies and mapped to the same locus of chromosome X in band q11. No amplification was found in other bovids and in particular in Bison, the closest related genus to the genus Bos. One copy of the amplified locus was cloned and sequenced. It encodes a protein sharing 95% identity with the human OZF protein. The bovine OZF gene was detected in an additional locus on chromosome 18 in both Bos and Bison, in band q23-24, which is likely to represent the ancestral position of the OZF gene. This is the first evidence of gene amplification in a mammalian species during evolution.

引用

页码：83 / 88

页数：6

共 22 条

[1] ONCOGENE AMPLIFICATION IN TUMOR-CELLS [J].