Enantioselective cyanoformylation of aldehydes mediated by BINOLAM-AlCl as a monometallic bifunctional catalyst

被引：87

作者：

Casas, J

Baeza, A

Sansano, JM

Nájera, C

Saá, JM

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain

[2] Univ Illes Balears, Dept Quim, E-07071 Palma de Mallorca, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(02)00824-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

BINOLAM-AlCl's, binaphthoxide aluminium chloride species generated in situ from either (R)- or (S)-3,3'-bis(diethylaminomethyl)-2,2'-dihydroxy-1,1'-binaphthalene (BINOLAM) behave as Lewis acid-Lewis base (LA-LB) catalysts in the enantioselective addition of methyl cyanoformate to aldehydes at room temperature, thereby leading to the asymmetric synthesis of (S)- or (R)-O-methoxycarbonyl cyanohydrins, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

共 33 条

[1]

AOI T, 1997, J AM CHEM SOC, V119, P5754

[2] Regioselective catalytic asymmetric reaction of Horner-Wadsworth-Emmons reagents with enones: The odyssey of chiral aluminum catalysts [J].