The serum level of Dickkopf-1 in patients with rheumatoid arthritis: A systematic review and meta-analysis

被引：43

作者：

Ma, Yubo ^{[1
,2
]}

Zhang, Xu ^{[1
,2
]}

Wang, Mengmeng ^{[1
,2
]}

Xia, Qing ^{[1
,2
]}

Yang, Jiajia ^{[1
,2
]}

Wu, Meng ^{[1
,2
]}

Han, Renfang ^{[1
,2
]}

Chen, Mengya ^{[1
,2
]}

Hu, Xingxing ^{[1
,2
]}

Yuan, Yaping ^{[1
,2
]}

Liu, Rui ^{[1
,2
]}

Jiang, Guangming ^{[1
,2
]}

Pan, Guixia ^{[1
,2
]}

Zou, Yanfeng ^{[1
,2
]}

Xu, Shengqian ^{[3
]}

Pan, Faming ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Key Lab Major Autoimmune Dis, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 1, Dept Rheumatism & Immun, Hefei 230032, Anhui, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2018年 / 59卷

基金：

中国国家自然科学基金;

关键词：

Rheumatoid arthritis; Dickkopf-1; DKK-1; RECEPTOR; CATENIN; INHIBITION; BIOMARKER; PROTEINS;

D O I：

10.1016/j.intimp.2018.04.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Objective: Dickkopf-1 (DKK-1) is an endogenous inhibitor of canonical Wnt pathway that was implicated in the pathogenesis of rheumatoid arthritis (RA), but the serum levels of DKK-1 in RA were inconsistent among studies. Therefore, we conducted a meta-analysis to systematically evaluate the relationship between serum DKK-1 levels and RA. Methods: PubMed, Web of Science and Cochrane Library were comprehensively retrieved till 1 January 2018 for pertinent studies. The pooled standard mean differences (SMDs) of serum DKK-1 levels were calculated according to the random effects model. Results: Nine original studies containing 1305 RA patients and 504 healthy controls were included in the meta analysis. The pooled SMD of serum DKK-1 between RA patients and healthy controls was 0.79 (95% CI = 0.11 to 1.48, Z = 2.28 and P = 0.023), indicating a significantly higher serum level of DKK-1 in RA patients. Conclusion: Serum level of DKK-1 is elevated in patients with RA compared to healthy controls, suggesting an important role of DKK-1 in the pathogenesis and treatment of RA.

引用

页码：227 / 232

页数：6

共 47 条

[1]

[Anonymous], 1998, BMJ

[2]

THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].