Human papillomavirus is not associated with colorectal cancer in a large international study

被引：56

作者：

Gornick, Michele C. ^{[1
]}

Castellsague, Xavier ^{[2
]}

Sanchez, Gloria ^{[3
]}

Giordano, Thomas J. ^{[4
]}

Vinco, Michelle ^{[4
]}

Greenson, Joel K. ^{[4
]}

Capella, Gabriel ^{[2
]}

Raskin, Leon ^{[5
]}

Rennert, Gad ^{[6
,7
,8
]}

Gruber, Stephen B. ^{[1
,5
,9
]}

Moreno, Victor ^{[2
,10
]}

机构：

[1] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[2] ESP, CIBER, ICO, IDIBELL, Barcelona, Spain

[3] Univ Antioquia, Bogota, Colombia

[4] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[6] Technion Israel Inst Technol, Dept Community Med & Epidemiol, Carmel Med Ctr, Haifa, Israel

[7] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Haifa, Israel

[8] Natl Israeli Canc Control Ctr, CHS, Haifa, Israel

[9] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[10] Univ Barcelona, Dept Clin Sci, Barcelona, Spain

来源：

CANCER CAUSES & CONTROL | 2010年 / 21卷 / 05期

关键词：

Human papillomavirus; Colorectal cancer; International study; SQUAMOUS-CELL CARCINOMA; POLYMERASE-CHAIN-REACTION; PENILE CARCINOMA; HIGH-RISK; IN-SITU; INFECTION; COLON; HPV; DNA; CLASSIFICATION;

D O I：

10.1007/s10552-010-9502-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer. The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15). All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method. We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

引用

页码：737 / 743

页数：7

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