Catalytic three-component coupling of alkynes, imines, and organoboron reagents

被引：170

作者：

Patel, SJ ^{[1
]}

Jamison, TF ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 12期

关键词：

alkynes; allylic annines; boronic acids; imines; nickel;

D O I：

10.1002/anie.200390349

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unusual degree of functional group compatibility for imine addition reactions was observed in the assembly of allylic amines from alkynes, imines, and organoboron reagents (boronic acids or boranes) by using a catalyst derived from [Ni(cod)2] and (c-C5H9)3P - this catalytic three-component process (see scheme) is tolerant of ketones, esters, and hydroxylic solvents.

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页码：1364 / 1367

页数：4

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