D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

被引：20

作者：

Anton, Andres ^{[1
]}

Angeles Marcos, Maria ^{[1
]}

Julian Martinez, Miguel ^{[1
]}

Ramon, Susana ^{[1
]}

Martinez, Anna ^{[2
]}

Cardenosa, Neus ^{[2
]}

Godoy, Pere ^{[2
]}

Torner, Nuria ^{[2
]}

De Molina, Patricia ^{[1
]}

Isanta, Ricard ^{[1
]}

Teresa Jimenez de Anta, Maria ^{[1
]}

Pumarola, Tomas ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Microbiol Lab, E-08036 Barcelona, Spain

[2] Generalitat Catalunya, Dept Hlth, Barcelona 08005, Spain

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2010年 / 67卷 / 02期

关键词：

Pandemic; Influenza; D225G mutation;

D O I：

10.1016/j.diagmicrobio.2010.02.002

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：207 / 208

页数：2

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