Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp MK929-43F1 -: Taxonomy, fermentation, isolation and biological activities

被引：117

作者：

Nakae, K

Yoshimoto, Y

Sawa, T

Homma, Y

Hamada, M

Takeuchi, T

Imoto, M

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 10期

关键词：

D O I：

10.7164/antibiotics.53.1130

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

引用

页码：1130 / 1136

页数：7

共 16 条

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