Reduced expression of connexin 31.1 in larynx cancer is not caused by GJB5 mutations

被引：6

作者：

Broghammer, M

Leistenschneider, P

Baus-Loncar, M

Blin, N

Sasiadek, MM

Pusch, CM

机构：

[1] Univ Tubingen, Inst Anthropol & Human Genet, Div Mol Genet, D-72074 Tubingen, Germany

[2] Wroclaw Med Univ, Inst Pathophysiol, PL-50368 Wroclaw, Poland

来源：

CANCER LETTERS | 2004年 / 214卷 / 02期

关键词：

cell-cell interaction; larynx cancer; loss of heterozygosity; transforming growth factor receptor;

D O I：

10.1016/j.canlet.2004.04.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Lack of regular cell-cell interaction is one major cause for neoplastic growth and metastasis. In head and neck squamous cell carcinomas a 10-fold down-regulation of connexin31.1 (GJB5) as well as mutations in the TGF-beta-receptor-II were reported. We performed mutation screenings in GJB5 and the TGF-beta-eceptor-II poly(10)adenine hot spot employing larynx cancer samples of 10 patient's. Variable length of the TGF-beta-receptor-II adenine hornopolymer in controls and tumours indicate a high slippage error rate of the DNA polymerases rendering mutational analyses inconsistent. Lack of GJB5 mutations in the entire tumour collection suggests that this gene is not primarily involved in laryngeal tumorigenesis. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：225 / 229

页数：5

共 27 条

[1]

Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells [J].