Making vascular networks in the adult: branching morphogenesis without a roadmap

被引：54

作者：

Dor, Y

Djonov, V

Keshet, E ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel

[2] Univ Bern, Dept Anat, CH-3000 Bern, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0962-8924(03)00022-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vascular system is unique in that extensive branching morphogenesis may take place in the adult. Developmental neovascularization is guided by precise spatial cues but vessel formation in the adult is not genetically programmed. Here, we review different adult modes for branch patterning, acquiring artery or vein identity and allocating vascular progenitor cells. The endothelium shows a remarkable degree of self-organization into a treelike network and hemodynamic forces are important in rectifying abnormal branching. This discussion is in the context of a contemplated therapy for improving organ perfusion by creating new vascular loops properly integrated within the existing network.

引用

页码：131 / 136

页数：6

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