Activation of development in mammals. Is there a role for a sperm cytosolic factor?

被引：64

作者：

Fissore, RA ^{[1
]}

Gordo, AC ^{[1
]}

Wu, H ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

来源：

THERIOGENOLOGY | 1998年 / 49卷 / 01期

关键词：

calcium; mammalian eggs; oscillin; G-proteins; tyrosine kinase;

D O I：

10.1016/S0093-691X(97)00401-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In mammalian oocytes, fertilization-associated calcium [Ca2+](i) oscillations are responsible for the activation of development. The mechanism(s) by which the sperm triggers the initial [Ca2+](i) rise and supports long-lasting oscillations is not resolved. It has been proposed that the sperm may interact with receptors in the oocyte's plasma membrane and engage intracellular signaling pathways that result in Ca2+ release. A different line of investigation suggests that upon sperm-oocyte fusion, a sperm cytosolic factor is released into the oocyte which interacts with unknown cytosolic targets, and generates [Ca2+](i) oscillations. We will discuss the most recent evidence for both lines of thought and demonstrate that injections of sperm crude extracts (SF) into mammalian oocytes trigger [Ca2+](i) oscillations that support in vitro parthenogenetic development to the blastocyst stage. (C) 1998 by Elsevier Science Inc.

引用

页码：43 / 52

页数：10

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