Uncovering cryptic genetic variation

被引:379
作者
Gibson, G [1 ]
Dworkin, I [1 ]
机构
[1] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrg1426
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations, and is thought to modify the penetrance of common diseases, the response of livestock and crops to artificial selection and the capacity of populations to respond to the emergence of a potentially advantageous macro-mutation. We argue in this review that cryptic genetic variation is pervasive but under-appreciated, we highlight recent progress in determining the nature and identity of genes that underlie cryptic genetic effects and we outline future research directions.
引用
收藏
页码:681 / U11
页数:10
相关论文
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