The pharmacokinetics, metabolism and urinary detection time of caffeine in camels

The pharmacokinetics of caffeine were determined in 10 camels after an intravenous dose of 2.35 mg kg(-1). The data obtained (median and range) were as follows. The elimination half-lift (t(1/2)) was 31.4 (21.2 to 58.9) hours, the steady state volume of distribution (V-ss) was 0.62 0.51 to 0.74) litre kg(-1) and the total body clearance (Cl-r) was 14.7 (8.70 to 19.7) mi I;gl per hour. Renal clearance estimated in two camels was 0.62 and 0.34 mi kg(-1) per hour. In vitro plasma protein binding (mean +/- SEM. n = 10) to a concentration of 2 and 8 mu g ml(-1) was 36.0 +/- 0.24 and 39.2 +/- 0.36 per cent respectively. Theophylline and theobromine were identified as caffeine metabolites in serum and urine. The terminal elimination half-lift of the former, estimated in two camels, was 70.4 and 124.4 hours. Caffeine could be detected in the urine for 14 days. (C) Harcourt Publishers Ltd.