Serum concentrations of TNF-α and soluble TNF-α receptors in obesity

被引：115

作者：

Zahorska-Markiewicz, B ^{[1
]}

Janowska, J ^{[1
]}

Olszanecka-Glinianowicz, M ^{[1
]}

Zurakowski, A ^{[1
]}

机构：

[1] Silesian Univ, Sch Med, Dept Pathophysiol, PL-40752 Katowice, Poland

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2000年 / 24卷 / 11期

关键词：

obesity; TNF alpha; soluble TNF receptors;

D O I：

10.1038/sj.ijo.0801398

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To study whether weight reducing treatment modulates serum concentration of TNF-alpha and two soluble TNF-alpha receptors in obese subjects. SUBJECTS AND MEASUREMENTS: Serum concentrations of TNF-alpha and two soluble receptors (sTNF-R1, sTNF-R2), plasma glucose, insulin, total cholesterol, HDL-cholesterol and triglicerides were measured in 27 obese subjects (age 48 +/- 12 y, body mass index (BMI): 36 +/- 6 kg/m(2)) before and after 3 months weight reducing treatment consisted of a diet & 1000 kcal/day and physical exercises. RESULTS: The mean loss of weight during 3 months' treatment was 9.3 +/- 3.3 kg. The serum concentration of TNF-alpha decreased after weight loss and at the same time both of the receptors (sTNF-R1,sTNF-R2) increased significantly. CONCLUSION: The observed decrease of the serum concentration of TNF-alpha and the increase in both TNF soluble receptors after weight reducing treatment in obese subjects, may be a counter-regulation preventing further weight loss.

引用

页码：1392 / 1395

页数：4

共 19 条

[1]

Bastard JP, 1999, DIABETES-METAB RES, V15, P92, DOI 10.1002/(SICI)1520-7560(199903/04)15:2<92::AID-DMRR21>3.3.CO

[2]

2-W

[3] Relationship between plasma leptin levels and the tumor necrosis factor-α system in obese subjects [J].

Corica, F ;

Allegra, A ;

Corsonello, A ;

Buemi, M ;

Calapai, G ;

Ruello, A ;

Mauro, VN ;

Ceruso, D .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (04) :355-360

[4] Tumor necrosis factor-α in sera of obese patients:: Fall with weight loss [J].

Dandona, P ;

Weinstock, R ;

Thusu, K ;

Abdel-Rahman, E ;

Aljada, A ;

Wadden, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (08) :2907-2910

[5] SOLUBLE RECEPTORS FOR TUMOR-NECROSIS-FACTOR IN CLINICAL LABORATORY DIAGNOSIS [J].

DIEZRUIZ, A ;

TILZ, GP ;

ZANGERLE, R ;

BAIERBITTERLICH, G ;

WACHTER, H ;

FUCHS, D .

EUROPEAN JOURNAL OF HAEMATOLOGY, 1995, 54 (01) :1-8

[6] Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance [J].

Fernández-Real, JM ;

Broch, M ;

Ricart, W ;

Casamitjana, R ;

Gutierrez, C ;

Vendrell, J ;

Richart, C .

DIABETES, 1998, 47 (11) :1757-1762

[7] Plasma concentrations of soluble TNF-alpha receptors in obese subjects [J].

Hauner, H ;

Bender, M ;

Haastert, B ;

Hube, F .

INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (12) :1239-1243

[8] ALTERED GENE-EXPRESSION FOR TUMOR-NECROSIS-FACTOR-ALPHA AND ITS RECEPTORS DURING DRUG AND DIETARY MODULATION OF INSULIN-RESISTANCE [J].

HOFMANN, C ;

LORENZ, K ;

BRAITHWAITE, SS ;

COLCA, JR ;

PALAZUK, BJ ;

HOTAMISLIGIL, GS ;

SPIEGELMAN, BM .

ENDOCRINOLOGY, 1994, 134 (01) :264-270

[9] INCREASED ADIPOSE-TISSUE EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA IN HUMAN OBESITY AND INSULIN-RESISTANCE [J].

HOTAMISLIGIL, GS ;

ARNER, P ;

CARO, JF ;

ATKINSON, RL ;

SPIEGELMAN, BM .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (05) :2409-2415

[10] REDUCED TYROSINE KINASE-ACTIVITY OF THE INSULIN-RECEPTOR IN OBESITY-DIABETES - CENTRAL ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA [J].

HOTAMISLIGIL, GS ;

BUDAVARI, A ;

MURRAY, D ;

SPIEGELMAN, BM .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (04) :1543-1549

← 1 2 →