Prevalence of activated protein C resistance in the Chinese population

In 1996, a total of 1700 subjects, including 461 healthy subjects and 1239 clinic patients, were randomized and consecutively entered into our study. Their mean age was 49.30+/-18.71 years, range 1-99 years. Of them, 1117 were male, and 583 were female. The mean age of the male was 42.96+/-17.64 years, and of the female, 52.60+/-18.41 years. The mean activated protein C ratio in 1700 subjects was 2.96+/-0.69, range 2.00-7.93. None of them had activated protein C ratio <2.0. The mean activated protein C ratio in the male was 2.81+/-0.63, and in the female was 3.04+/-0.71. None of the subjects was found to have activated protein C resistance. DNA analysis for the Arg 506-Gln mutation was also performed on 492 out of the 1700 subjects; none of them had this mutation. We suggested that the Chinese is not a race with the trait of activated protein C resistance. (C) 1998 Elsevier Science Ltd.