Neutrophils scan for activated platelets to initiate inflammation

被引：521

作者：

Sreeramkumar, Vinatha ^{[1
]}

Adrover, Jose M. ^{[1
]}

Ballesteros, Ivan ^{[2
,3
]}

Isabel Cuartero, Maria ^{[2
,3
]}

Rossaint, Jan ^{[4
,5
]}

Bilbao, Izaskun ^{[1
,6
]}

Nacher, Maria ^{[1
,7
]}

Pitaval, Christophe ^{[1
]}

Radovanovic, Irena ^{[1
]}

Fukui, Yoshinori ^{[8
]}

McEver, Rodger P. ^{[9
]}

Filippi, Marie-Dominique ^{[10
]}

Lizasoain, Ignacio ^{[2
,3
]}

Ruiz-Cabello, Jesus ^{[1
,6
]}

Zarbock, Alexander ^{[4
,5
]}

Moro, Maria A. ^{[2
,3
]}

Hidalgo, Andres ^{[1
,11
]}

机构：

[1] CNIC, Dept Atherothrombosis Imaging & Epidemiol, Madrid, Spain

[2] Univ Complutense Madrid, Fac Med, Dept Pharmacol, Unidad Invest Neurovasc, E-28040 Madrid, Spain

[3] Hosp 12 Octubre I 12, Inst Invest, Madrid, Spain

[4] Univ Munster, Dept Anesthesiol & Crit Care Med, D-48149 Munster, Germany

[5] Max Planck Inst Munster, Munster, Germany

[6] Ciber Enfermedades Resp CIBERES, Madrid, Spain

[7] Univ Wollongong, Fac Sci Med & Hlth, Wollongong, NSW 2522, Australia

[8] Kyushu Univ, Dept Immunobiol & Neurosci, Div Immunogenet, Fukuoka 812, Japan

[9] Oklahoma Med Res Fdn, Cardiovasc Biol Res Program, Oklahoma City, OK 73104 USA

[10] Univ Cincinnati, Coll Med, Cincinnati Childrens Res Fdn, Div Expt Hematol & Canc Biol, Cincinnati, OH USA

[11] Univ Munich, Inst Cardiovasc Prevent, Munich, Germany

来源：

SCIENCE | 2014年 / 346卷 / 6214期

基金：

日本学术振兴会;

关键词：

EXTRACELLULAR TRAPS; LEUKOCYTE; MICRODOMAINS; CHEMOTAXIS; MOTILITY; ADHESION; POLARITY; CASCADE; SIGNALS; INJURY;

D O I：

10.1126/science.1256478

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.

引用

页码：1234 / 1238

页数：5

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