The impact of L1 retrotransposons on the human genome

被引：391

作者：

Kazazian, HH ^{[1
]}

Moran, JV ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

来源：

NATURE GENETICS | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1038/ng0598-19

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.

引用

页码：19 / 24

页数：6

共 68 条

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