High Prevalence of Vitamin D Deficiency among Inner-City African American Youth with Asthma in Washington, DC

被引:134
作者
Freishtat, Robert J. [1 ,2 ,5 ,6 ]
Iqbal, Sabah F. [1 ,2 ,5 ,6 ]
Pillai, Dinesh K. [2 ,4 ,5 ,6 ]
Klein, Catherine J. [3 ,5 ]
Ryan, Leticia M. [1 ,3 ,5 ]
Benton, Angela S. [2 ]
Teach, Stephen J. [1 ,3 ,5 ]
机构
[1] Childrens Natl Med Ctr, Div Emergency Med, Washington, DC 20010 USA
[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA
[3] Childrens Natl Med Ctr, Ctr Clin & Community Res, Washington, DC 20010 USA
[4] Childrens Natl Med Ctr, Div Pulm Med, Washington, DC 20010 USA
[5] George Washington Univ, Sch Med & Hlth Sci, Dept Pediat, Washington, DC 20052 USA
[6] George Washington Univ, Sch Med & Hlth Sci, Dept Integrat Syst Biol, Washington, DC 20052 USA
基金
美国国家卫生研究院;
关键词
NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; UNITED-STATES; CHILDREN; 25-HYDROXYVITAMIN-D; PREGNANCY; CANCER; RISK; NEED; AGE;
D O I
10.1016/j.jpeds.2009.12.033
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective The goal of this study was to examine the prevalence of vitamin D insufficiency and deficiency among urban African-American (AA) youth with asthma compared with control subjects without asthma. Study design A cross-sectional case-control study was conducted at an urban pediatric medical center. Total 25-hydroxyvitamin D insufficiency (< 30 ng/mL) and deficiency (< 20 ng/mL) were assessed in urban self-reported AA patients, aged 6 to 20 years, with (n = 92) and without (n = 21) physician-diagnosed asthma. Results Blood samples were available for 85 (92%) cases. The prevalence of vitamin D insufficiency and deficiency were significantly greater among cases than control subjects (73/85 [86%] vs 4/21 [19%], adjusted odds ratio = 42 [95% confidence interval: 4.4 to 399] for insufficiency and 46/85 [54%] vs 1/21 [5%], adjusted odds ratio = 20 [95% confidence interval: 1.4 to 272] for deficiency). Conclusions Most of this sample of urban AA youth with persistent asthma were vitamin D deficient or insufficient. Given the emerging associations between low vitamin D levels and asthma, strong consideration should be given to routine vitamin D testing in urban AA youth, particularly those with asthma. (J Pediatr 2010;156:948-52).
引用
收藏
页码:948 / 952
页数:5
相关论文
共 39 条
[1]   The burden of asthma with specific reference to the United States [J].
Beasley, R .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (05) :S482-S489
[2]   Low vitamin D status despite abundant sun exposure [J].
Binkley, N. ;
Novotny, R. ;
Krueger, D. ;
Kawahara, T. ;
Daida, Y. G. ;
Lensmeyer, G. ;
Hollis, B. W. ;
Drezner, M. K. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (06) :2130-2135
[3]   Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes [J].
Bischoff-Ferrari, Heike A. ;
Giovannucci, Edward ;
Willett, Walter C. ;
Dietrich, Thomas ;
Dawson-Hughes, Bess .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 84 (01) :18-28
[4]   Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica [J].
Brehm, John M. ;
Celedon, Juan C. ;
Soto-Quiros, Manuel E. ;
Avila, Lydiana ;
Hunninghake, Gary M. ;
Forno, Erick ;
Laskey, Daniel ;
Sylvia, Jody S. ;
Hollis, Bruce W. ;
Weiss, Scott T. ;
Litonjua, Augusto A. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (09) :765-771
[5]  
BURR M L, 1989, Archives of Disease in Childhood, V64, P1452, DOI 10.1136/adc.64.10.1452
[6]   Prospective study of maternal intake of vitamin D during pregnancy and risk of wheezing illnesses in children at age 2 years [J].
Camargo, CA ;
Rifas-Shiman, SL ;
Litonjua, AA ;
Rich-Edwards, JW ;
Weiss, ST ;
Gold, DR ;
Gillman, MW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (03) :721-722
[7]   Epidemic influenza and vitamin D [J].
Cannell, J. J. ;
Vieth, R. ;
Umhau, J. C. ;
Holick, M. F. ;
Grant, W. B. ;
Madronich, S. ;
Garland, C. F. ;
Giovannucci, E. .
EPIDEMIOLOGY AND INFECTION, 2006, 134 (06) :1129-1140
[8]   How accurate are assays for 25-hydroxyvitamin D? Data from the international vitamin D external quality assessment scheme [J].
Carter, GD ;
Carter, R ;
Jones, J ;
Berry, J .
CLINICAL CHEMISTRY, 2004, 50 (11) :2195-2197
[9]  
CLEMENS TL, 1982, LANCET, V1, P74
[10]   Maternal vitamin D intake during pregnancy and early childhood wheezing [J].
Devereux, Graham ;
Litonjua, Augusto A. ;
Turner, Stephen W. ;
Craig, Leone C. A. ;
McNeill, Geraldine ;
Martindale, Sheelagh ;
Helms, Peter J. ;
Seaton, Anthony ;
Weiss, Scott T. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (03) :853-859