Telomere states and cell fates

被引：1064

作者：

Blackburn, EH ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA

来源：

NATURE | 2000年 / 408卷 / 6808期

关键词：

D O I：

10.1038/35040500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomere length has frequently been used as a means to predict the future life of cells. But by itself it can be a poor indicator of ageing or cell viability. What, then, is the important property of a telomere? Here recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.

引用

页码：53 / 56

页数：4

共 48 条

[1] MRT-2 checkpoint protein is required for germline immortality and telomere replication in C-elegans
Ahmed, S
Hodgkin, J
[J]. NATURE, 2000, 403 (6766) : 159 - 164
[2] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
ALLSOPP, RC
VAZIRI, H
PATTERSON, C
GOLDSTEIN, S
YOUNGLAI, EV
FUTCHER, AB
GREIDER, CW
HARLEY, CB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10114 - 10118
[3] [Anonymous], TELOMERES TELOMERASE
[4] Telomere variation in Xenopus laevis
Bassham, S
Beam, A
Shampay, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) : 269 - 275
[5] Telomeres and double-strand breaks: trying to make ends meet
Bertuch, A
Lundblad, V
[J]. TRENDS IN CELL BIOLOGY, 1998, 8 (09) : 339 - 342
[6] Blackburn E, 1999, MT SINAI J MED, V66, P292
[7] BLACKBURN EH, IN PRESS COLD SPRING
[8] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
Blasco, MA
Lee, HW
Hande, MP
Samper, E
Lansdorp, PM
DePinho, RA
Greider, CW
[J]. CELL, 1997, 91 (01) : 25 - 34
[9] Extension of life-span by introduction of telomerase into normal human cells
Bodnar, AG
Ouellette, M
Frolkis, M
Holt, SE
Chiu, CP
Morin, GB
Harley, CB
Shay, JW
Lichtsteiner, S
Wright, WE
[J]. SCIENCE, 1998, 279 (5349) : 349 - 352
[10] Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
Counter, CM
Hahn, WC
Wei, WY
Caddle, SD
Beijersbergen, RL
Lansdorp, PM
Sedivy, JM
Weinberg, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14723 - 14728

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