What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?

被引：28

作者：

Altamura, C.

Squitti, R.

Pasqualetti, P.

Tibuzzi, F.

Silvestrini, M.

Ventriglia, M. C.

Cassetta, E.

Rossini, P. M.

Vernieri, F.

机构：

[1] Univ Campus Biomed Roma, Dept Neurosci, I-00128 Rome, Italy

[2] AFaR, Rome, Italy

[3] Osp Fatebenefratelli, Dept Neurosci, Rome, Italy

[4] Univ Politecn Madrid, Neurol Clin, Ancona, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2007年 / 14卷 / 06期

关键词：

alzheimer dementia; apolipoprotein E polymorphism; carotid atherosclerosis; intimamedia thickness; vascular dementia;

D O I：

10.1111/j.1468-1331.2007.01714.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Evidence suggests the important role of vascular factors both in vascular dementia (VaD) and Alzheimer disease (AD) pathogenesis. However, the relationship between apolipoprotein E (APOE) polymorphism and markers of atherosclerosis is still controversial. The aim of the study was to investigate the interplay between APOE polymorphisms and atherosclerosis in patients with AD and VaD. In this cross-sectional study, 101 demented (68 AD and 33 VaD) patients underwent APOE genotyping and neck vessel ultrasound to evaluate carotid artery disease [intima-media thickness (IMT) and plaques]. Patients with AD carrying epsilon 4 allele presented increased IMT values with respect to non-epsilon 4 carriers and VaD patients, whereas no relation was found between APOE polymorphisms and the presence or grade of carotid plaques both in AD and VaD patients. The epsilon 4 APOE allele may promote intima-media thickening, interacting with other factors contributing to AD development.

引用

页码：679 / 682

页数：4

共 15 条

[1] Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening - Results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS) [J].