Enantioselective reduction of aromatic and aliphatic ketones catalyzed by ruthenium complexes attached to β-cyclodextrin

被引：129

作者：

Schlatter, A ^{[1
]}

Kundu, MK ^{[1
]}

Woggon, WD ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 48期

关键词：

asymmetric catalysis; cyclodextrins; reduction; ruthenium; transfer hydrogenation;

D O I：

10.1002/anie.200460102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble chiral Ru complexes with a β-cyclodextrin unit have been shown to catalyze the reduction of aliphatic ketones (see scheme) with up to 97% ee and in good to excellent yields in the presence of sodium formate. The β-cyclodextrin unit is an essential component of the catalyst. It contributes to the unprecedented levels of enantioselectivity observed through the preorganization of the substrates in the hydrophobic cavity.

引用

页码：6731 / 6734

页数：4

共 22 条

[1] Ru(arene)(amino alcohol)-catalyzed transfer hydrogenation of ketones: Mechanism and origin of enantioselectivity [J].