Formation of iron-sulfur clusters in bacteria: an emerging field in bioinorganic chemistry

被引:182
作者
Frazzon, J [1 ]
Dean, DR
机构
[1] Univ Fed Rio Grande do Sul, Dept Food Sci, ICTA, BR-91051970 Porto Alegre, RS, Brazil
[2] Virginia Tech, Dept Biochem, Blacksburg, VA 24060 USA
关键词
D O I
10.1016/S1367-5931(03)00021-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Biological iron-sulfur clusters are chemically versatile inorganic structures that are attached to many proteins. These clusters are intimately involved in the functions of their partner proteins and they are required to sustain life on earth. Recent work has demonstrated that, in spite of their simple structures, the assembly and insertion of iron-sulfur clusters into their protein partners is a complex biological process. This complexity is probably related to the cellular toxicity of iron and sulfur in their free forms.
引用
收藏
页码:166 / 173
页数:8
相关论文
共 58 条
  • [1] Modular organization and identification of a mononuclear iron-binding site within the NifU protein
    Agar, JN
    Yuvaniyama, P
    JAck, RF
    Cash, VL
    Smith, AD
    Dean, DR
    Johnson, MK
    [J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2000, 5 (02): : 167 - 177
  • [2] IscU as a scaffold for iron-sulfur cluster biosynthesis: Sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU
    Agar, JN
    Krebs, C
    Frazzon, J
    Huynh, BH
    Dean, DR
    Johnson, MK
    [J]. BIOCHEMISTRY, 2000, 39 (27) : 7856 - 7862
  • [3] Role of the IscU protein in iron-sulfur cluster biosynthesis:: IscS-mediated assembly of a [Fe2S2] cluster in IscU
    Agar, JN
    Zheng, LM
    Cash, VL
    Dean, DR
    Johnson, MK
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (09) : 2136 - 2137
  • [4] Iron-sulfur clusters: Nature's modular, multipurpose structures
    Beinert, H
    Holm, RH
    Munck, E
    [J]. SCIENCE, 1997, 277 (5326) : 653 - 659
  • [5] Crystal structure of the cystine C-S lyase from Synechocystis:: Stabilization of cysteine persulfide for FeS cluster biosynthesis
    Clausen, T
    Kaiser, JT
    Steegborn, C
    Huber, R
    Kessler, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) : 3856 - 3861
  • [6] AZOTOBACTER-VINELANDII NIFD-ENCODED AND NIFE-ENCODED POLYPEPTIDES SHARE STRUCTURAL HOMOLOGY
    DEAN, DR
    BRIGLE, KE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) : 5720 - 5723
  • [7] Nitrogenase MoFe-protein at 1.16 Å resolution:: A central ligand in the FeMo-cofactor
    Einsle, O
    Tezcan, FA
    Andrade, SLA
    Schmid, B
    Yoshida, M
    Howard, JB
    Rees, DC
    [J]. SCIENCE, 2002, 297 (5587) : 1696 - 1700
  • [8] NUCLEOTIDE-SEQUENCE AND GENETIC-ANALYSIS OF THE AZOTOBACTER-CHROOCOCCUM NIFUSVWZM GENE-CLUSTER, INCLUDING A NEW GENE (NIFP) WHICH ENCODES A SERINE ACETYLTRANSFERASE
    EVANS, DJ
    JONES, R
    WOODLEY, PR
    WILBORN, JR
    ROBSON, RL
    [J]. JOURNAL OF BACTERIOLOGY, 1991, 173 (17) : 5457 - 5469
  • [9] NIFU GENE-PRODUCT FROM AZOTOBACTER-VINELANDII IS A HOMODIMER THAT CONTAINS 2 IDENTICAL [2FE-2S] CLUSTERS
    FU, WG
    JACK, RF
    MORGAN, TV
    DEAN, DR
    JOHNSON, MK
    [J]. BIOCHEMISTRY, 1994, 33 (45) : 13455 - 13463
  • [10] Structure of a NifS homologue:: X-ray structure analysis of CsdB, an Escherichia coli counterpart of mammalian selenocysteine lyase
    Fujii, T
    Maeda, M
    Mihara, H
    Kurihara, T
    Esaki, N
    Hata, Y
    [J]. BIOCHEMISTRY, 2000, 39 (06) : 1263 - 1273