Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)

被引：39

作者：

Broadhurst, MJ ^{[1
]}

Brown, PA ^{[1
]}

Lawton, G ^{[1
]}

Ballantyne, N ^{[1
]}

Borkakoti, N ^{[1
]}

Bottomley, KMK ^{[1
]}

Cooper, MI ^{[1
]}

Eatherton, AJ ^{[1
]}

Kilford, IR ^{[1
]}

Malsher, PJ ^{[1
]}

Nixon, JS ^{[1
]}

Lewis, EJ ^{[1
]}

Sutton, BM ^{[1
]}

Johnson, WH ^{[1
]}

机构：

[1] ROCHE DISCOVERY WELWYN,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00416-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid-and osteoarthritis. (C) 1997 Elsevier Science Ltd.

引用

页码：2299 / 2302

页数：4

共 15 条

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