Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46

被引:79
作者
Mori, Y
Yang, XW
Akkapaiboon, P
Okuno, T
Yamanishi, K
机构
[1] Osaka Univ, Med Sch C1, Dept Microbiol, Suita, Osaka 5650871, Japan
[2] Hyogo Med Univ, Dept Microbiol, Nishinomiya, Hyogo 6638501, Japan
关键词
D O I
10.1128/JVI.77.8.4992-4999.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46.
引用
收藏
页码:4992 / 4999
页数:8
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