Malaria vaccines-targeting infected hepatocytes

被引：47

作者：

Hoffman, SL ^{[1
]}

Doolan, DL

机构：

[1] USN, Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA

[2] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 11期

关键词：

D O I：

10.1038/81315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Developing a modern vaccine that is able to duplicate the protective immunity observered after immunization with irradiated P. falciparum (Pf) sporozoites requires identification of antigenic Pf proteins. The identification of Pf Liver Stage Antigen-3 and its ability to protect chimpanzees against sporozoite challenge suggests we are headed in the right direction (pages 1258–1263).

引用

页码：1218 / 1219

页数：2

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