Cytokine control of memory T-cell development and survival

被引:707
作者
Schluns, KS [1 ]
Lefrançois, L [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Div Immunol, Farmington, CT 06030 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri1052
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8(+) T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family - in particular, interleukin-7 (IL-7) and IL-15 - act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8(+) T-cell pool can be propagated and maintained.
引用
收藏
页码:269 / 279
页数:11
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