Recognition of a non-standard base pair by thermostable DNA polymerases

被引：32

作者：

Lutz, MJ

Horlacher, J

Benner, SA

机构：

[1] ETH Zurich, Dept Chem, CH-8092 Zurich, Switzerland

[2] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00177-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Examination of several commercially available thermostable DNA polymerases identifies 9 degrees N DNA polymerase as single enzyme that could incorporate two components of an expanded genetic alphabet, 2,4-diaminopyrimidine and xanthosine as deoxynucleoside triphosphate opposite their cognate base in a DNA template. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1149 / 1152

页数：4

共 18 条

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