Screening of some marine organism extracts for cAMP phosphodiesterase inhibition, cytotoxicity, and antiviral activity against HSV-1

被引：8

作者：

Arisawa, M

Hayashi, K

Nikaido, T

Koike, K

Fujita, D

Nunomura, N

Tanaka, M

Sasaki, T

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,LAB HERBAL GARDEN,TOYAMA 93001,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,FAC MED,DEPT VIROL,TOYAMA 93001,JAPAN

[3] TOHO UNIV,SCH PHARMACEUT SCI,DEPT PHARMACOGNOSY,FUNABASHI,CHIBA 274,JAPAN

[4] TOYAMA PREFECTURAL FISHERIES RES INST,TOYAMA 936,JAPAN

[5] TOYAMA SCI MUSEUM,TOYAMA 939,JAPAN

[6] KANAZAWA UNIV,CANC RES INST,DEPT EXPT THERAPEUT,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1997年 / 35卷 / 01期

关键词：

marine product; inhibitor; cyclicAMP phosphodiesterase; cytotoxic activity; KB cell; antiviral activity; herpes simplex virus type 1;

D O I：

10.1076/phbi.35.1.6.13265

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Methanol and hot water extracts of 71 samples of 56 kinds of marine products were sujected to inhibitory test for cyclic AMP phosphodiesterase (cAMP PDE), cytotoxic and anti-viral screening tests. Among them, 7 extracts of marine products showed a significant inhibition for cAMP PDE and 5 extracts showed a significant cytotoxicity against KB cells at concentrations under 20 mu g/ml. Eight extracts of marine products showed higher therapeutic indexes against herpes simplex virus type 1 (HSV-1).

引用

页码：6 / 11

页数：6

共 18 条

[1]

Arisawa Munehisa, 1994, Natural Medicines, V48, P338

[2]

SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL N-SUBSTITUTED DERIVATIVES OF ACYCLOVIR [J].