B-cell receptor regulation of peripheral B cells

被引：47

作者：

MacLennan, ICM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Immunol, Birmingham B15 2TT, W Midlands, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(98)80252-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that immature B cells compete with recirculating B cells for survival signals. The signals, delivered through the B-cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-producing cells. (C) Current Biology Ltd ISSN 0952-7915.

引用

页码：220 / 225

页数：6

共 50 条

[1]

ALLMAN DM, 1993, J IMMUNOL, V151, P4431

[2]

BAZIN H, 1985, IMMUNOLOGY, V54, P79

[3] ONLY A SMALL PROPORTION OF SPLENIC B-CELLS IN ADULTS ARE SHORT-LIVED VIRGIN CELLS [J].

CHAN, EYT ;

MACLENNAN, ICM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (02) :357-363

[4] THE SITE AND STAGE OF ANTI-DNA B-CELL DELETION [J].

CHEN, C ;

NAGY, Z ;

RADIC, MZ ;

HARDY, RR ;

HUSZAR, D ;

CAMPER, SA ;

WEIGERT, M .

NATURE, 1995, 373 (6511) :252-255

[5] SYK TYROSINE KINASE REQUIRED FOR MOUSE VIABILITY AND B-CELL DEVELOPMENT [J].

CHENG, AM ;

ROWLEY, B ;

PAO, W ;

HAYDAY, A ;

BOLEN, JB ;

PAWSON, T .

NATURE, 1995, 378 (6554) :303-306

[6] Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy [J].

Cook, MC ;

Basten, A ;

Fazekas de St Groth, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (05) :631-643

[7] Signaling thresholds and interclonal competition in preimmune B-cell selection [J].

Cyster, JG .

IMMUNOLOGICAL REVIEWS, 1997, 156 :87-101

[8] Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate [J].

Cyster, JG ;

Goodnow, CC .

IMMUNITY, 1995, 3 (06) :691-701

[9] Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 [J].

Cyster, JG ;

Healy, JI ;

Kishihara, K ;

Mak, TW ;

Thomas, ML ;

Goodnow, CC .

NATURE, 1996, 381 (6580) :325-328

[10] COMPETITION FOR FOLLICULAR NICHES EXCLUDES SELF-REACTIVE CELLS FROM THE RECIRCULATING B-CELL REPERTOIRE [J].

CYSTER, JG ;

HARTLEY, SB ;

GOODNOW, CC .

NATURE, 1994, 371 (6496) :389-395

← 1 2 3 4 5 →