Analytical spectroscopic tools for high-throughput screening of combinatorial materials libraries

This paper summarizes our recent activities to develop analytical spectroscopic tools for high-throughput screening of combinatorial materials libraries and the adaptation of the developed techniques for measurements on more traditional scales. The development strategies are presented, followed by the review of requirements for monitoring of chemical reactions in combinatorial and scaled-up reactors. Examples are provided to detail development of multivariate data-analysis methods for prediction of properties of combinatorial materials, determination of contributing factors to combinatorial-scale chemical reactions, and high-throughput optimization of process parameters. (C) 2003 Published by Elsevier Science B.V.