In Vitro Antimicrobial Activity and Mutant Prevention Concentration of Colistin against Acinetobacter baumannii

被引：36

作者：

Cai, Yun ^{[1
]}

Li, Ran ^{[1
]}

Liang, Beibei ^{[1
]}

Bai, Nan ^{[1
]}

Liu, Youning ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Dept Clin Pharmacol, Beijing 100853, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期

关键词：

RESISTANT;

D O I：

10.1128/AAC.00264-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antimicrobial activities of colistin and other antibiotics against clinical Acinetobacter baumannii and the mutant prevention concentration (MPC) of colistin against multidrug-resistant A. baumannii were studied. All 70 stains tested were sensitive to colistin. The MPC range of colistin against 30 multidrug-resistant A. baumannii stains was approximately 32 to >128 mu g/ml, and the MPC at which 90% of the isolates tested were prevented (MPC(90)) exceeded 128 mu g/ml, which was much higher than the plasma concentration of colistin at the current recommended dosage. So, combination therapy for colistin treatment of A. baumannii would be prudent to slow the emergence of resistance.

引用

页码：3998 / 3999

页数：2

共 7 条

[1] Mutant selection window hypothesis updated [J].

Drlica, Karl ;

Zhao, Xilin .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (05) :681-688

[2] Polymyxin B: similarities to and differences from colistin (polymyxin E) [J].

Kwa, Andrea ;

Kosiakou, Sofia K. ;

Tam, Vincent H. ;

Falagas, Matthew E. .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2007, 5 (05) :811-821

[3] Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, gram-negative bacilli infections: A prospective, open-label, uncontrolled study [J].

Markou, Nikolaos ;

Markantonis, Sophia L. ;

Dirnitrakis, Efthirnios ;

Panidis, Dimitris ;

Boutzouka, Eleni ;

Karatzas, Styllanos ;

Rafailidis, Petros ;

Apostolakos, Haralarnpos ;

Baltopoulos, George .

CLINICAL THERAPEUTICS, 2008, 30 (01) :143-151

[4] Colistin in the 21st century [J].

Nation, Roger L. ;

Li, Jian .

CURRENT OPINION IN INFECTIOUS DISEASES, 2009, 22 (06) :535-543

[5] Comparison of Escherichia coli uropathogenic genes (kps, usp and ireA) and enteroaggregative genes (aggR and aap) via multiplex polymerase chain reaction from suprapubic urine specimens of young children with fever [J].

Park, Hae-Kyung ;

Jung, Yun-Jae ;

Chae, Hee-Chung ;

Shin, Yoo-Jung ;

Woo, So-Youn ;

Park, Hye-Sook ;

Lee, Seung-Joo .

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2009, 43 (01) :51-57

[6] Acinetobacter baumannii:: Emergence of a successful pathogen [J].

Peleg, Anton Y. ;

Seifert, Harald ;

Paterson, David L. .

CLINICAL MICROBIOLOGY REVIEWS, 2008, 21 (03) :538-582

[7] Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus [J].

Zhao, XL ;

Eisner, W ;

Perl-Rosenthal, N ;

Kreiswirth, B ;

Drlica, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (03) :1023-1027

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