Dynamic development of the pancreas from birth to adulthood

被引：64

作者：

Bonner-Weir, Susan ^{[1
]}

Aguayo-Mazzucato, Cristina ^{[1
]}

Weir, Gordon C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 2016年 / 121卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Beta cells; neogenesis; postnatal growth; CARBONIC-ANHYDRASE-II; BETA-CELL GROWTH; MATURATION; ENDOCRINE; ISLETS; REGENERATION; EXPRESSION; SECRETION;

D O I：

10.3109/03009734.2016.1154906

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of pre-existing cells and by new differentiation (neogenesis) across the first postnatal weeks, with the result of beta cells of different stages of maturation even after weaning. Improving our understanding of this period of beta cell expansion could provide valuable therapeutic insights.

引用

收藏

页码：155 / 158

页数：4

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