Peptide T bolus normalizes the growth hormone secretion pattern in two children with AIDS

被引：4

作者：

Barbey-Morel, C

McDonnell, K

Pert, CB

Adams, M

Farrand, D

Ruff, MR

Lumpkin, MD

机构：

[1] Georgetown Univ, Sch Med, Dept Physiol & Biophys, Washington, DC 20057 USA

[2] Adv Immuni T Inc, Stony Brook, NY 11790 USA

来源：

PEPTIDES | 2002年 / 23卷 / 12期

关键词：

peptide T; AIDS wasting; gp120; growth hormone; growth hormone releasing hormone receptor; pediatric AIDS; HIV envelope protein;

D O I：

10.1016/S0196-9781(02)00268-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In humans, HIV infection reduces growth hormone (GH) secretion contributing to AIDS wasting. In rats, the HIV envelope protein gp120 alone blocks GH secretion both in vitro and in vivo through GH-releasing hormone receptors. Peptide T, a modified octapeptide derived from gp120, normalizes GH secretion. We now report that an intravenous bolus of peptide T normalizes nocturnal GH secretion in two out of three children with AIDS. These results, coupled with the lack of toxicity of this experimental AIDS therapeutic, justify clinical trials for AIDS wasting and pediatric AIDS. A clinical and basic science update on peptide T appears in Current HIV Research. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：2279 / 2281

页数：3

共 9 条

[1] PACAP FUNCTIONS AS A NEUROTROPHIC FACTOR [J].

ARIMURA, A ;

SOMOGYVARIVIGH, A ;

WEILL, C ;

FIORE, RC ;

TATSUNO, I ;

BAY, V ;

BRENNEMAN, DE .

MODELS OF NEUROPEPTIDE ACTION, 1994, 739 :228-243

[2] D-[ALA1]-PEPTIDE T-AMIDE IS TRANSPORTED FROM BLOOD TO BRAIN BY A SATURABLE SYSTEM [J].

BARRERA, CM ;

KASTIN, AJ ;

BANKS, WA .

BRAIN RESEARCH BULLETIN, 1987, 19 (06) :629-633

[3] VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death [J].

Brenneman, DE ;

Hauser, J ;

Spong, CY ;

Phillips, TM ;

Pert, CB ;

Ruff, M .

BRAIN RESEARCH, 1999, 838 (1-2) :27-36

[4] HIV gp120 inhibits the somatotropic axis: A possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting [J].

Mulroney, SE ;

McDonnell, KJ ;

Pert, CB ;

Ruff, MR ;

Resch, Z ;

Samson, WK ;

Lumpkin, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1927-1932

[5]

RATNER KF, 1997, J ACQ IMMUN DEF SYND, V15, P137

[6] Peptide T blocks GP120/CCR5 chemokine receptor-mediated chemotaxis [J].

Redwine, LS ;

Pert, CB ;

Rone, JD ;

Nixon, R ;

Vance, M ;

Sandler, B ;

Lumpkin, MD ;

Dieter, DJ ;

Ruff, MR .

CLINICAL IMMUNOLOGY, 1999, 93 (02) :124-131

[7] Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5) [J].

Ruff, MR ;

Melendez-Guerrero, LM ;

Yang, QE ;

Ho, WZ ;

Mikovits, JW ;

Pert, CB ;

Ruscetti, FA .

ANTIVIRAL RESEARCH, 2001, 52 (01) :63-75

[8] Recombinant human growth hormone in patients with HIV-associated wasting - A randomized, placebo-controlled trial [J].

Schambelan, M ;

Mulligan, K ;

Grunfeld, C ;

Daar, ES ;

LaMarca, A ;

Kotler, DP ;

Wang, J ;

Bozzette, SA ;

Breitmayer, JB ;

Hurley, A ;

Javaly, K ;

Pitt, J ;

Pang, M ;

Heald, AE ;

Shipp, KW ;

Pearce, D ;

Sova, K ;

Pate, P ;

Boswell, SL ;

Flynn, T ;

Polsky, B ;

Haverstick, L ;

Rothkopf, MM ;

Bliffen, DL ;

Rosenfeld, R ;

Pierson, RN ;

Winson, G ;

Tai, V ;

Bennison, WM ;

Kennedy, SM ;

Neu, TK ;

Robinson, CE ;

Schwalbert, RJ ;

LaMarca, D ;

Kuritzkes, DR ;

Ray, MG ;

Mellors, JW ;

Balser, BE ;

Balser, JP .

ANNALS OF INTERNAL MEDICINE, 1996, 125 (11) :873-+

[9]

1989, 4 INT AIDS C

← 1 →