Better nephrology for mice-and man

被引：34

作者：

Breyer, Matthew D. ^{[1
]}

Qi, Zhonghua ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Biotechnol Discovery Res, Indianapolis, IN 46285 USA

来源：

KIDNEY INTERNATIONAL | 2010年 / 77卷 / 06期

关键词：

GLOMERULAR-FILTRATION-RATE; SERUM CREATININE; RENAL-FUNCTION; CLEARANCE;

D O I：

10.1038/ki.2009.544

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The use of creatinine to estimate glomerular filtration rate in patients is prone to well-described artifacts that impact its interpretation. Eisner et al. now show that the impact of creatinine secretion on creatinine clearance is even larger in mice than in humans, raising questions regarding the utility of creatinine for measuring glomerular filtration rate in mice. Kidney International (2010) 77, 487-489. doi: 10.1038/ki.2009.544

引用

页码：487 / 489

页数：4

共 11 条

[1]

[Anonymous], 2002, AM J KIDNEY DIS

[2] Utility of endogenous creatinine clearance as a measure of renal function in mice [J].

Dunn, SR ;

Qi, ZH ;

Bottinger, EP ;

Breyer, MD ;

Sharma, K .

KIDNEY INTERNATIONAL, 2004, 65 (05) :1959-1967

[3] Major contribution of tubular secretion to creatinine clearance in mice [J].

Eisner, Christoph ;

Faulhaber-Walter, Robert ;

Wang, Yaohui ;

Leelahavanichkul, Asada ;

Yuen, Peter S. T. ;

Mizel, Diane ;

Star, Robert A. ;

Briggs, Josephine P. ;

Levine, Mark ;

Schnermann, Jurgen .

KIDNEY INTERNATIONAL, 2010, 77 (06) :519-526

[4] PICRIC ACID METHODS GREATLY OVERESTIMATE SERUM CREATININE IN MICE - MORE ACCURATE RESULTS WITH HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

MEYER, MH ;

MEYER, RA ;

GRAY, RW ;

IRWIN, RL .

ANALYTICAL BIOCHEMISTRY, 1985, 144 (01) :285-290

[5]

Palmer MA, 2005, FRONT ECOL ENVIRON, V3, P4, DOI 10.1890/1540-9295(2005)003[0004:ESASFT]2.0.CO

[6]

[7]

PERRONE RD, 1992, CLIN CHEM, V38, P1933

[8] Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance [J].

Qi, ZH ;

Whitt, I ;

Mehta, A ;

Jin, JP ;

Zhao, M ;

Harris, RC ;

Fogo, AB ;

Breyer, MD .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 286 (03) :F590-F596

[9] LIMITATIONS OF CREATININE AS A FILTRATION MARKER IN GLOMERULOPATHIC PATIENTS [J].

SHEMESH, O ;

GOLBETZ, H ;

KRISS, JP ;

MYERS, BD .

KIDNEY INTERNATIONAL, 1985, 28 (05) :830-838

[10] A study of the germ cells of aphis ros AE and aphis OE nother AE [J].

Stevens, NM .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1905, 2 (03) :313-U5

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