Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-γ and IL-4 expression in psoriatic skin in situ

被引：20

作者：

Piskin, G ^{[1
]}

Heydendael, VMR ^{[1
]}

de Rie, MA ^{[1
]}

Bos, JD ^{[1
]}

Teunissen, MBM ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, NL-1100 DE Amsterdam, Netherlands

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2003年 / 294卷 / 12期

关键词：

T cell; IL-4; psoriasis; IFN-gamma; methotrexate; cyclosporin A;

D O I：

10.1007/s00403-002-0353-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

[No abstract available]

引用

页码：559 / 562

页数：4

共 17 条

[1] Novel immunotherapies for psoriasis [J].

Asadullah, K ;

Volk, HD ;

Sterry, W .

TRENDS IN IMMUNOLOGY, 2002, 23 (01) :47-53

[2] Interleukin 10 treatment of psoriasis -: Clinical results of a phase 2 trial [J].

Asadullah, K ;

Döcke, WD ;

Ebeling, M ;

Friedrich, M ;

Belbe, G ;

Audring, H ;

Volk, HD ;

Sterry, W .

ARCHIVES OF DERMATOLOGY, 1999, 135 (02) :187-192

[3] The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations:: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients [J].

Austin, LM ;

Ozawa, M ;

Kikuchi, T ;

Walters, IB ;

Krueger, JG .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (05) :752-759

[4] THE EFFECTS OF CYCLOSPORINE-A ON LYMPHOCYTE-T AND DENDRITIC CELL SUBPOPULATIONS IN PSORIASIS [J].

BAKER, BS ;

GRIFFITHS, CEM ;

LAMBERT, S ;

POWLES, AV ;

LEONARD, JN ;

VALDIMARSSON, H ;

FRY, L .

BRITISH JOURNAL OF DERMATOLOGY, 1987, 116 (04) :503-510

[5] The pathogenesis of psoriasis: Immunological facts and speculations [J].

Bos, JD ;

De Rie, MA .

IMMUNOLOGY TODAY, 1999, 20 (01) :40-46

[6] Cyclosporine restores cytokine imbalance in childhood atopic dermatitis [J].

Campbell, DE ;

Kemp, AS .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (06) :857-859

[7]

Constantin A, 1998, ARTHRITIS RHEUM, V41, P48, DOI 10.1002/1529-0131(199801)41:1<48::AID-ART7>3.3.CO

[8]

2-B

[9] SEVERE PSORIASIS - ORAL THERAPY WITH A NEW RETINOID [J].

FREDRIKSSON, T ;

PETTERSSON, U .

DERMATOLOGICA, 1978, 157 (04) :238-244

[10] Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells [J].

Genestier, L ;

Paillot, R ;

Fournel, S ;

Ferraro, C ;

Miossec, P ;

Revillard, JP .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (02) :322-328

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