Dual infections of the central nervous system with Epstein-Barr virus

被引：75

作者：

Weinberg, A

Bloch, KC

Li, SB

Tang, YW

Palmer, M

Tyler, KL

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Pediat, Denver, CO 80262 USA

[2] Univ Colorado, Sch Med, Dept Med, Denver, CO 80262 USA

[3] Univ Colorado, Sch Med, Dept Neurol, Denver, CO 80262 USA

[4] Univ Colorado, Sch Med, Dept Immunol, Denver, CO 80262 USA

[5] Univ Colorado, Sch Med, Dept Microbiol, Denver, CO 80262 USA

[6] Denver Vet Affairs Med Ctr, Denver, CO USA

[7] Vanderbilt Univ, Dept Med, Nashville, TN USA

[8] Vanderbilt Univ, Dept Prevent Med, Nashville, TN USA

[9] Vanderbilt Univ, Dept Pathol, Nashville, TN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷 / 02期

关键词：

D O I：

10.1086/426402

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe clinical and laboratory characteristics of 16 patients with central nervous system (CNS) infection caused by Epstein-Barr virus (EBV) and another pathogen. Seven of 10 immunocompromised patients had coinfection with viruses (3 with cytomegalovirus, 2 with JC virus, and 2 with varicella zoster virus) and 3 with nonviral pathogens (2 with pneumococcus and 1 with Cryptococcus species). Three of 6 immunocompetent patients had coinfections with viruses (1 each with herpes simplex virus, varicella zoster virus, and West Nile virus), and 3 had coinfections with nonviral pathogens (2 with Ehrlichia chaffeensis and 1 with Mycoplasma pneumoniae). The EBV load was similar in immunocompromised and immunocompetent patients and in patients with viral and nonviral coinfections. EBV lytic-cycle mRNA was detected in the cerebrospinal fluid of 5 of 6 tested samples, indicating EBV replication in the CNS during coinfection.

引用

页码：234 / 237

页数：4

共 9 条

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