Opinion - Regulated exocytosis: new organelles for non-secretory purposes

被引:96
作者
Chieregatti, E [1 ]
Meldolesi, J [1 ]
机构
[1] Vita Salute San Raffaele Univ, Dept Neurosci, Ctr Excellence Cellular Pathophysiol, San Raffaele Sci Inst, I-20132 Milan, Italy
关键词
D O I
10.1038/nrm1572
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Regulated exocytosis is a process in which the membranes of cytoplasmic organelles fuse with the plasma membrane in response to stimulation. In many cases (secretory exocytoses), the process functions to secrete specific products that are segregated in the organelle lumen (for example, neurotransmitters, hormones and enzymes) to the extracellular space. In other cases ('non-secretory exocytoses'), it functions to transfer the organelle membrane and its components to the cell surface. Here, the general properties of non-secretory exocytoses are discussed.
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收藏
页码:181 / 187
页数:7
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共 67 条
[1]   Syntaxin 3 is required for cAMP-induced acid secretion: streptolysin O-permeabilized gastric gland model [J].
Ammar, DA ;
Zhou, RH ;
Forte, JG ;
Yao, XB .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (01) :G23-G33
[2]   DYNAMIC CHANGES IN ULTRASTRUCTURE OF ACINAR CELL OF RAT PAROTID GLAND DURING SECRETORY CYCLE [J].
AMSTERDAM, A ;
OHAD, I ;
SCHRAMM, M .
JOURNAL OF CELL BIOLOGY, 1969, 41 (03) :753-+
[3]   Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation [J].
Bajno, L ;
Peng, XR ;
Schreiber, AD ;
Moore, HP ;
Trimble, WS ;
Grinstein, S .
JOURNAL OF CELL BIOLOGY, 2000, 149 (03) :697-705
[4]   Defective membrane repair in dysferlin-deficient muscular dystrophy [J].
Bansal, D ;
Miyake, K ;
Vogel, SS ;
Groh, S ;
Chen, CC ;
Williamson, R ;
McNeil, PL ;
Campbell, KP .
NATURE, 2003, 423 (6936) :168-172
[5]   Rapid vesicular translocation and insertion of TRP channels [J].
Bezzerides, VJ ;
Ramsey, IS ;
Kotecha, S ;
Greka, A ;
Clapham, DE .
NATURE CELL BIOLOGY, 2004, 6 (08) :709-720
[6]   Secretory lysosomes [J].
Blott, EJ ;
Griffiths, GM .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (02) :122-131
[7]   Regulated exocytosis: a novel, widely expressed system [J].
Borgonovo, B ;
Cocucci, E ;
Racchetti, G ;
Podini, P ;
Bachi, A ;
Meldolesi, J .
NATURE CELL BIOLOGY, 2002, 4 (12) :955-962
[8]   AMPA receptor trafficking at excitatory synapses [J].
Bredt, DS ;
Nicoll, RA .
NEURON, 2003, 40 (02) :361-379
[9]   The ins and outs of aquaporin-2 trafficking [J].
Brown, D .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (05) :F893-F901
[10]   Secretory granule exocytosis [J].
Burgoyne, RD ;
Morgan, A .
PHYSIOLOGICAL REVIEWS, 2003, 83 (02) :581-632