Defining an epigenetic code

被引：265

作者：

Turner, Bryan M. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Biomed Res Inst, Birmingham B15 2TT, W Midlands, England

来源：

NATURE CELL BIOLOGY | 2007年 / 9卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/ncb0107-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.

引用

页码：2 / 6

页数：5

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