MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization

被引：5893

作者：

Katoh, Kazutaka ^{[1
]}

Rozewicki, John ^{[1
]}

Yamada, Kazunori D. ^{[2
,3
]}

机构：

[1] Osaka Univ, Res Inst Microbial Dis, Dept Genome Informat, Suita, Osaka, Japan

[2] Tohoku Univ, Grad Sch informat Sci, Sendai, Miyagi, Japan

[3] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 565, Japan

来源：

BRIEFINGS IN BIOINFORMATICS | 2019年 / 20卷 / 04期

基金：

日本学术振兴会;

关键词：

multiple sequence alignment; sequence analysis; phylogenetic tree; CHAINED GUIDE TREES; PREDICTIONS; STRATEGY; QUALITY; SERVER;

D O I：

10.1093/bib/bbx108

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This article describes several features in the MAFFT online service for multiple sequence alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers of biological sequences are available and the need for MSAs with large numbers of sequences is increasing. To extract biologically relevant information from such data, sophistication of algorithms is necessary but not sufficient. Intuitive and interactive tools for experimental biologists to semiautomatically handle large data are becoming important. We are working on development of MAFFT toward these two directions. Here, we explain (i) the Web interface for recently developed options for large data and (ii) interactive usage to refine sequence data sets and MSAs.

引用

页码：1160 / 1166

页数：7

共 42 条

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