Hydride reagents for stereoselective reductive amination. An improved preparation of 3-endo-tropanamine

被引：28

作者：

McGill, JM

LaBell, ES

Williams, M

机构：

[1] Chemical Process Development, Tippecanoe Laboratories, Division of Eli Lilly and Company, Lafayette

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 23期

关键词：

D O I：

10.1016/0040-4039(96)00760-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reductive amination of substituted cyclohexanones with sodium triacyloxyborohydrides derived from NaBH4 and various carboxylic acids provides highly diastereoselective conversions to protected axial amines. This method was applied to the stereoselective preparation of 3-endo-tropanamine. (C) 1996 Elsevier Science Ltd

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页码：3977 / 3980

页数：4

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