Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

被引：76

作者：

Augustin, Shana M. ^{[1
]}

Lovinger, David M. ^{[1
]}

机构：

[1] NIAAA, Lab Integrat Neurosci, NIH, Rockville, MD 20852 USA

来源：

ACS CHEMICAL NEUROSCIENCE | 2018年 / 9卷 / 09期

关键词：

Arachidonoylethanolamine; 2-arachidonoylglycerol; cannabinoid receptors; depolarization-induced suppression of inhibition; depolarization-induced suppression of excitation; long-term depression; long-term potentiation; LONG-TERM DEPRESSION; DEPOLARIZATION-INDUCED SUPPRESSION; CANNABINOID CB1 RECEPTOR; MOUSE VISUAL-CORTEX; RAT BARREL CORTEX; TEMPORAL-LOBE EPILEPSY; MEDIUM SPINY NEURONS; PRIMARY SOMATOSENSORY CORTEX; DIACYLGLYCEROL LIPASE-ALPHA; CRITICAL PERIOD PLASTICITY;

D O I：

10.1021/acschemneuro.7b00508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.

引用

页码：2146 / 2161

页数：16

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