The histamine H4 receptor and potential therapeutic uses for H4 ligands

被引:33
作者
Jablonowski, JA [1 ]
Carruthers, NI [1 ]
Thurmond, RL [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA
关键词
D O I
10.2174/1389557043403152
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Histamine is a biogenic amine that plays a host of physiological roles and the three major functions for histamine have been largely defined by the activity of three receptors. The inflammatory wheal and flare response is driven by the H-1 receptor [1]. The H-2 receptor controls gastric acid secretion in the gut [2]. The H-3 receptor is involved in neurotransmitter release in the central nervous system [3]. The recent discovery of the histamine H-4 receptor by several groups has lead to the re-evaluation of the physiological role for histamine.
引用
收藏
页码:993 / 1000
页数:8
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