Synthesis and biological evaluation of novel cyclosporin A analogues: Potential soft drugs for the treatment of autoimmune diseases

被引：23

作者：

Lazarova, T ^{[1
]}

Chen, JS ^{[1
]}

Hamann, B ^{[1
]}

Kang, JM ^{[1
]}

Hoinuth-Trombino, D ^{[1
]}

Han, F ^{[1
]}

Hoffmann, E ^{[1
]}

McClure, C ^{[1
]}

Eckstein, J ^{[1
]}

Or, YS ^{[1
]}

机构：

[1] Enanta Pharmaceut, Watertown, MA 02472 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 05期

关键词：

D O I：

10.1021/jm025595i

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.

引用

页码：674 / 676

页数：3

共 17 条

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