Sharpless asymmetric dihydroxylation on an industrial scale

被引：49

作者：

Ahrgren, L ^{[1
]}

Sutin, L ^{[1
]}

机构：

[1] Pharmacia & Upjohn AB, S-75182 Uppsala, Sweden

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1997年 / 1卷 / 06期

关键词：

D O I：

10.1021/op970030v

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

It is shown in this study that the inexpensive N-methylmorpholine N-oxide can be successfully employed as a reoxidant in the Sharpless asymmetric dihydroxylation reaction on a large scale, The reaction of o-isopropoxy-m-methoxystyrene on a 2 kg scale gave the corresponding diol in high yield and high enantiomeric excess. The extension of this synthetic method to other olefins is also presented.

引用

页码：425 / 427

页数：3

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