The superfamily of heptahelical receptors

被引：174

作者：

Lefkowitz, RJ ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med Cardiol, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 07期

关键词：

D O I：

10.1038/35017152

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and the beta(2)-adrenergic receptor, and of the existence of a larger 'superfamily' of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.

引用

页码：E133 / E136

页数：4

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