Molecular regulation of cognitive functions and developmental plasticity:: impact of GABAA receptors

被引：113

作者：

Moehler, Hanns

机构：

[1] Univ Zurich, Inst Pharmacol, CH-8057 Zurich, Switzerland

[2] Swiss Fed Inst Technol, ETH, Dept Chem & Appl Biosci, Zurich, Switzerland

[3] Coll Helveticum, Zurich, Switzerland

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 102卷 / 01期

关键词：

anxiety; memory; schizophrenia; sensory processing; sleep; AMINOBUTYRIC ACID(A) RECEPTORS; INTERNEURON DIVERSITY SERIES; ALPHA-5; SUBUNIT; BENZODIAZEPINE SITE; INVERSE AGONIST; PHARMACOLOGICAL CHARACTERIZATION; NETWORK OSCILLATIONS; PHASE PRECESSION; TONIC INHIBITION; SUBTYPES;

D O I：

10.1111/j.1471-4159.2007.04454.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in regulating neuronal circuits and behavior. The pronounced diversity of GABAergic (gamma-aminobutyric acid) interneurons is paralleled by an extensive diversity of GABA(A) receptor subtypes. The region- and domain-specific location of these receptor subtypes offers the opportunity to gain functional insights into the role of defined neuronal circuits. These developments are reviewed with regard to the regulation of sleep, anxiety, memory, sensorimotor processing and post-natal developmental plasticity.

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页码：1 / 12

页数：12

相关论文

共 140 条

[1] The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone [J].

Atack, John R. ;

Pike, Andy ;

Marshall, George ;

Stanley, Jo ;

Lincoln, Rachael ;

Cook, Susan M. ;

Lewis, Richard T. ;

Blackaby, Wesley P. ;

Goodacre, Simon C. ;

McKernan, Ruth M. ;

Dawson, Gerard R. ;

Wafford, Keith A. ;

Reynolds, David S. .

NEUROPHARMACOLOGY, 2006, 50 (06) :677-689

[2] TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for α2-and α3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates [J].

Atack, JR ;

Wafford, KA ;

Tye, SJ ;

Cook, SM ;

Sohal, B ;

Pike, A ;

Sur, C ;

Melillo, D ;

Bristow, L ;

Bromidge, F ;

Ragan, I ;

Kerby, J ;

Street, L ;

Carling, R ;

Castro, JL ;

Whiting, P ;

Dawson, GR ;

McKernan, RM .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 316 (01) :410-422

[3] Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABAA receptors [J].

Atack, JR ;

Hutson, PH ;

Collinson, N ;

Marshall, G ;

Bentley, G ;

Moyes, C ;

Cook, SM ;

Collins, I ;

Wafford, K ;

McKernan, RM ;

Dawson, GR .

BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (03) :357-366

[4] Contributions of GABAA receptor subtype selectivity to abuse liability and dependence potential of pharmacological treatments for anxiety and sleep disorders [J].

Ator, NA .

CNS SPECTRUMS, 2005, 10 (01) :31-39

[5]

Barnard EA, 1998, PHARMACOL REV, V50, P291

[6] Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks [J].

Bartos, Marlene ;

Vida, Imre ;

Jonas, Peter .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (01) :45-56

[7] Neurosteroids:: Endogenous regulators of the GABAA receptor [J].

Belelli, D ;

Lambert, JJ .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (07) :565-575

[8] Pharmacology of recombinant γ-aminobutyric acida receptors rendered diazepam-insensitive by point-mutated α-subunits [J].

Benson, JA ;

Löw, K ;

Keist, R ;

Mohler, H ;

Rudolph, U .

FEBS LETTERS, 1998, 431 (03) :400-404

[9]

Bianchi MT, 2003, J NEUROSCI, V23, P10934

[10] The 'ABC' of GABA receptors [J].

Bormann, J .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (01) :16-19

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